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Document 0311
DOCN M9460311
TI Inactivation of HIV, HBV, HCV related viruses and other viruses in human
plasma derivatives by pasteurisation.
DT 9408
AU Nowak T; Niedrig M; Bernhardt D; Hilfenhaus J; Microbiology Research
Laboratories, Behringwerke AG, Marburg,; Germany.
SO Dev Biol Stand. 1993;81:169-76. Unique Identifier : AIDSLINE
MED/94229370
AB Laboratory studies were made to verify the capacity and efficacy of the
pasteurisation step (heat treatment at 60 degrees C for 10 hours in
stabilized aqueous solution) in inactivating various pathogenic viruses
(e.g. HIV, HBV, HCV related viruses, HAV, HSV, poliovirus). These
experiments proved that pasteurisation effectively inactivates a broad
spectrum of viruses with a range of different physicochemical
properties. The results, summarized in inactivation kinetics,
demonstrate that complete inactivation of high quantities of both
enveloped (e.g. HIV, HCV related viruses) and non-enveloped (e.g.
poliovirus) viruses takes place during pasteurisation. In clinical
trials on the virus safety of plasma derivatives no case of AIDS,
hepatitis B or C occurred. From these data we conclude that heat
treatment at 60 degrees C in a stabilized aqueous solution confers a
high margin of safety on human plasma protein preparations regarding the
transmission of diseases such as AIDS or hepatitis.
DE *Biological Products Clinical Trials Drug Contamination/PREVENTION &
CONTROL Flaviviridae/PHYSIOLOGY *Heat Hepatitis B Virus/*PHYSIOLOGY
Hepatitis C Viruses/*PHYSIOLOGY Human HIV/*PHYSIOLOGY Kinetics
Picornaviridae/PHYSIOLOGY Plasma/*MICROBIOLOGY Prospective Studies
Safety Virus Diseases/PREVENTION & CONTROL Virus Replication JOURNAL
ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).